Browsing by Author "Strati, Katerina"
Now showing items 1-17 of 17
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Article
Changing stem cell dynamics during papillomavirus infection: Potential roles for cellular plasticity in the viral lifecycle and disease
Strati, Katerina (2017)Stem cells and cellular plasticity are likely important components of tissue response to infection. There is emerging evidence that stem cells harbor receptors for common pathogen motifs and that they are receptive to local ...
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Conference Object
Contextual Bandits for Adapting Treatment in a Mouse Model of de Novo Carcinogenesis
Durand, Audrey; Achilleos, Charis; Iacovides, Demetris; Strati, Katerina; Mitsis, Georgios D.; Pineau, Joelle (2018)In this work, we present a specific case study where we aim to design effective treatment allocation strategies and validate these using a mouse model of skin cancer. Collecting data for modelling ...
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Article
Deficiencies in the Fanconi Anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer
Park, J. W.; Pitot, H. C.; Strati, Katerina; Spardy, N.; Duensing, S.; Grompe, M.; Lambert, P. F. (2010)Patients with the rare genetic disease, Fanconi anemia (FA), are highly susceptible to squamous cell carcinomas arising at multiple anatomic sites including the head and neck region. Human papillomaviruses (HPVs), particularly ...
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Article
Direct conversion of mouse embryonic fibroblasts into functional keratinocytes through transient expression of pluripotency-related genes
Iacovides, D.; Rizki, G.; Lapathitis, Georgios; Strati, Katerina (2016)The insufficient ability of specialized cells such as neurons, cardiac myocytes, and epidermal cells to regenerate after tissue damage poses a great challenge to treat devastating injuries and ailments. Recent studies ...
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Article
The HPV16 oncogenes cause aberrant stem cell mobilization
Michael, S.; Lambert, P. F.; Strati, Katerina (2013)Human Papilloma Virus related epithelial cancers have been speculated to derive from virus-infected tissue stem cells. Stem cells also are thought to provide a reservoir of latently infected cells that can persist for long ...
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Article
Human papillomavirus association with head and neck cancers: Understanding virus biology and using it in the development of cancer diagnostics
Strati, Katerina; Lambert, P. F. (2008)The link between human papillomaviruses (HPVs) and human cervical cancers has long been established. However, HPVs are now being detected in another type of cancer not previously associated with this virus, head and neck ...
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Article
Human papillomavirus type 16 E6 and E7 oncoproteins act synergistically to cause head and neck cancer in mice
Jabbar, S.; Strati, Katerina; Shin, M. K.; Pitot, H. C.; Lambert, P. F. (2010)High-risk human papillomaviruses (HPVs) contribute to cervical and other anogenital cancers, and they are also linked etiologically to a subset of head and neck squamous cell carcinomas (HNSCC). We previously established ...
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Article
Identification of biomarkers that distinguish human papillomavirus (HPV)-positive versus HPV-negative head and neck cancers in a mouse model
Strati, Katerina; Pitot, H. C.; Lambert, P. F. (2006)Head and neck squamous cell carcinoma (HNSCC) is a leading cause of cancer mortality worldwide. Recent reports have associated a subset of HNSCC with high-risk human papillomaviruses (HPVs), particularly HPV16, the same ...
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Article
The Ink4/Arf locus is a barrier for iPS cell reprogramming
Li, H.; Collado, M.; Villasante, A.; Strati, Katerina; Ortega, S.; Cãamero, M.; Blasco, M. A.; Serrano, M. (2009)The mechanisms involved in the reprogramming of differentiated cells into induced pluripotent stem (iPS) cells by the three transcription factors Oct4 (also known as Pou5f1), Klf4 and Sox2 remain poorly understood. The ...
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Article
Model-based tumor growth dynamics and therapy response in a mouse model of de novo carcinogenesis
Loizides, Constantinos A.; Iacovides, D.; Hadjiandreou, M. M.; Rizki, G.; Achilleos, Achilleas P.; Strati, Katerina; Mitsis, Georgios D. (2015)Tumorigenesis is a complex, multistep process that depends on numerous alterations within the cell and contribution from the surrounding stroma. The ability to model macroscopic tumor evolution with high fidelity may ...
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Article
A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
Marión, R. M.; Strati, Katerina; Li, H.; Murga, M.; Blanco, R.; Ortega, S.; Fernandez-Capetillo, O.; Serrano, M.; Blasco, M. A. (2009)The reprogramming of differentiated cells to pluripotent cells (induced pluripotent stem (iPS) cells) is known to be an inefficient process. We recently reported that cells with short telomeres cannot be reprogrammed to ...
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Article
Regulating cellular plasticity to persist: a way for tumor viruses to triumph
Yilmaz, Vural; Strati, Katerina (2019)Viruses can cause cancer either by direct (e.g. expression of viral oncogenes) or indirect (e.g. immunomodulation) means. A pre-requisite to carcinogenesis is long-term infection of the natural niche, indicating an important ...
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Article
Role of Rb-dependent and Rb-independent functions of papillomavirus E7 oncogene in head and neck cancer
Strati, Katerina; Lambert, P. F. (2007)Infection with high-risk human papillomaviruses (HPV) and in particular the expression of the viral proteins E6 and E7 have been associated with the etiology of a subset of head and neck squamous cell cancer (HNSCC). ...
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Article
Shared mechanisms in stemness and carcinogenesis: Lessons from oncogenic viruses
Iacovides, D.; Michael, S.; Achilleos, Charis; Strati, Katerina (2013)A rise in technologies for epigenetic reprogramming of cells to pluripotency, highlights the potential of understanding and manipulating cellular plasticity in unprecedented ways. Increasing evidence points to shared ...
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Article
Telomeres Acquire Embryonic Stem Cell Characteristics in Induced Pluripotent Stem Cells
Marion, R. M.; Strati, Katerina; Li, H.; Tejera, A.; Schoeftner, S.; Ortega, S.; Serrano, M.; Blasco, M. A. (2009)Telomere shortening is associated with organismal aging. iPS cells have been recently derived from old patients
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Article
Terc is dispensable for most of the short-term HPV16 oncogene-mediated phenotypes in mice
Achilleos, Charis; Michael, Stella; Strati, Katerina (2018)High-risk human papillomaviruses (HPVs) have been shown in vitro to impinge on telomere homeostasis in a number of ways. However, the in vivo interaction of viruses with the telomere homeostasis apparatus has not been ...
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Article
Whole transcriptome sequence data of 5-FU sensitive and 5-FU resistant tumors generated in a mouse model of de novo carcinogenesis
Iacovides, Demetris; Loizides, Charalambos; Mitsis, Georgios; Strati, Katerina (2018)We have performed whole transcriptome sequencing of 5-FU resistant and 5-FU sensitive tumors generated in a mouse model of de novo carcinogenesis that closely recapitulates tumor initiation, progression and maintenance in ...